Stem Cells-Immune cell Interactions during Tissue Regeneration

Adult stem cells are responsible for the maintenance and regeneration of various tissues and appendages. As a group of long-lived cells, over their life cycle, a major challenge for these indispensable cells is the frequent exposure to waves of inflammation that could be caused by infections or injury. In order to maintain tissue homeostasis, stem cells must endure these repeated bouts of inflammation. Despite the physiological significance of this feature, it is unclear how adult stem cells adapt to inflammation, how inflammation impacts tissue stem cells and how do stem cells achieve self-renewal and differentiation within an inflammatory environment. An important direction of Miao lab is to decode the crosstalk between normal tissue adult stem cell and various immune populations to achieve immune adaptation. The information from this research is the key to understand tissue fitness, stress adaptation and disease tolerance.