Stem Cell-specific Immune Evasion Mechanisms in Cancer

Our recent work has revealed a superior capacity of tumor-initiating stem cells to survive from robust immunotherapy treatment and to drive tumor relapse. Built on these previous findings, another important research direction of Miao lab is to systematically decipher the immune evasive mechanisms unique to tumor-initiating stem cells in various epithelial cancers. We particularly focus on how do these highly plastic cells reprogram their epigenome and metabolisms to achieve immune evasion. The key to overcoming cancer immune resistance may rely on developing therapeutic strategies against cancer stem cells as the next generation of immunotherapy.