Innate Immune Mechanisms Sensing Oncogenic Events in Stem Cells

As long-lived cells residing within the tissue, adult stem cells are faced with the dilemma of needing to tolerate harmless mutations but also needing to detect and respond to those that are oncogenic. Therefore, tight but balanced immune sensing and removal of only aberrant SCs are critical for governing tissue homeostasis. The third direction of Miao laboratory is to explore how adult stem cells sense their own oncogenic alterations and communicate with sentinel innate immune cells to evoke robust immune surveillance. The ultimate goal of this study is to understand how these processes have gone awry during tumorigenesis, so we can harness the power of innate immunity to design novel immunotherapy.